Endocrine Abstracts

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...

Purpose: Vasomotor symptoms (VMS) adversely affect postmenopausal quality of life. However, their impact on bone health has not been elucidated. This study aimed to systematically review and meta-analyze the evidence regarding the association of VMS with fracture risk and bone mineral density (BMD) in peri- and postmenopausal women.Methods: A literature search was conducted in PubMed, Scopus and Cochrane databases until 31 August 2023. Fracture, low BMD ...

Objective: Kidney function is known to be interrelated with the aging process. On the other hand, a number of studies support a link between the menopausal transition and kidney function, either directly or indirectly, secondary to the effect of the alternating hormone environment or the effect of the accumulated cardiovascular risk factors, respectively. We aimed to evaluate the cross-sectional association between kidney function and sex hormones at the time of the menopausal...

Background: Cardiovascular disease remains the leading cause of death worldwide, affecting both sexes. Awareness and prevention practices aiming to control cardiovascular risk in women remain inadequate. On the other hand, circulating amyloid β 1-40 (Aβ1-40) is a proatherogenic peptide, closely linked with the process of aging. We aimed to evaluate the possible association between the progression of atherosclerosis in postmenopausal women and the role of Aβ1-40 ...

Background: A large body of evidence is supporting that the incidence of adverse cardiovascular events is increasing signfiicantly after the menopausal transition. Primary prevention practices continue to propose evolving algorithms, in an attempt to accurately estimate the actual female cardiovascular risk at midlife. Irrespectively of these attempts, considerable unrecognized cardiovascular disease (CVD) risk remains unexplained, beyond traditional risk factors (TRFs). On th...

Background: Both surgical and spontaneous menopause are associated with increased cardiovascular disease (CVD) risk. Recent evidence reported that clusters of menopausal symptoms are associated with accumulation of cardiometabolic risk factors. Climacteric symptoms are also known to be affected by lifestyle parameters, ethnicity, the geographical location as well as by the overall health status at the time of the menopausal transition.Aim: This study aim...

Heterozygotes carrying CYP21A2 gene mutations are found in 5-10% of the general population in Mediterranean countries. Accumulating data suggest a survival advantage of this population, despite the fact that carriers of two mutations suffer from either classical or non-classical congenital adrenal hyperplasia (NC-CAH), an entity with increased mortality. In an attempt to elaborate on this issue we evaluated females of reproductive age with CYP21A2 heterozygocity (HET). We have...

Objective: To evaluate the association between genetic background and the presence of oligo- or amenorrhea in a sample of adolescent girls diagnosed with anorexia nervosa compared with controls.Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calculated body mass index (BMI) z-scores adjusted for age, as wel...

Introduction: The aim of this study was to evaluate the association between a personal history of lactation and indices of subclinical atherosclerosis and arterial stiffness in postmenopausal women.Patients and methods: This cross-sectional study included 283 postmenopausal women. Sonographically assessed indices of vascular function [pulse wave velocity (PWV)] and vascular structure [intima-media thickness (IMT), atherosclerotic plaque presence] were te...

Introduction: A growing body of evidence is supporting a beneficial impact of breastfeeding on maternal metabolism and overall cardiovascular risk. The aim of this study was to evaluate the association between prolactin levels and metabolic parameters as well as indices of subclinical atherosclerosis, in a sample of premenopausal women with normal levels of prolactin.Patients and Methods: This cross-sectional study included a total of 64 non-lactating pr...